Clinical studies

The efficacy of CEFALY has been demonstrated by clinical studies that have been carried out since 2008. The validated results have been published in highly respected medical journals.

Acute treatment of migraine

Type of clinical studyConclusionScientific publication
Double-blind versus placeboSedative effectBMC Neurology 2011
Pilot open trialEffective for acute treatment of migraine attacksNeuromodulation 2017
SurveyEffective for users in “real world”Acta Neurol Belg. 2017
Pivotal Randomized Double-blind versus placeboEffective and safe for acute treatment of migraine attacksClinicalTrials. gov
Pilot open trialEffective for migraine abortionClinicalTrials. gov

Migraine Prevention

Type of clinical studyConclusionScientific publication
Pivotal Randomized Double-blind versus placeboEffective at preventing migraineNeurology 2013
Cohort of 2300 patientsBest safety for migraine treatmentJournal of Headache and Pain 2013
Responders rateFirst line treatmentJournal of Headache and Pain 2015
Prospective study on chronic migraineEffective on chronic migraineNeurological Sciences ​2017
Prospective exploratory on refractory migraineEffective on refractory migraineBMC Neurology ​2017

Neurophysiology and Mechanism of action

Type of clinical studyConclusionScientific publication
PET ScanCentral action of CefalyCephalalgia 2016
Action mechanismCurrent knowledge on mechanisms on trigeminal nerveInternal Medicine Review 2017
fMRICentral action of CefalyFrontiers in Neurology​2017
ReviewPrevious data confirmationPain and Therapy journal 2015
Evoked Cortical PotentialCentral action of CefalyCephalalgia 2018
ReviewRationale for electrical parametersCephalalgia 2018