Clinical studies

The efficacy of CEFALY has been demonstrated by clinical studies that have been carried out since 2008. The validated results have been published in highly respected medical journals.

Acute treatment of migraine

Type of clinical study

  • Double-blind versus placebo
  • Pilot open trial
  • Survey
  • Pivotal Randomized Double-blind versus
  • placebo
  • Pilot open trial

Conclusion

  • Sedative effect
  • Effective for acute treatment of migraine attacks
  • Effective for users in “real world”
  • Effective and safe for acute treatment of migraine attacks
  • Effective for migraine abortion

Scientific publication

  • BMC Neurology 2011
  • Neuromodulation 2017
  • Acta Neurol Belg. 2017
  • ClinicalTrials. gov
  • ClinicalTrials. gov

Migraine Prevention

Type of clinical study

  • Pivotal Randomized Double-blind versus placebo
  • Cohort of 2300 patients
  • Responders rate
  • Prospective study on chronic migraine
  • Prospective exploratory on refractory migraine

Conclusion

  • Effective at preventing migraine
  • Best safety for migraine treatment
  • First line treatment
  • Effective on chronic migraine
  • Effective on refractory migraine

Scientific publication

  • Neurology 2013
  • Journal of Headache and Pain 2013
  • Journal of Headache and Pain 2015
  • Neurological Sciences ​2017
  • BMC Neurology ​2017

Neurophysiology and Mechanism of action

Type of clinical study

  • PET Scan
  • Action mechanism
  • fMRI
  • Review
  • Evoked Cortical Potential
  • Review

Conclusion

  • Central action of Cefaly
  • Current knowledge on mechanisms on trigeminal nerve
  • Central action of Cefaly
  • Previous data confirmation
  • Central action of Cefaly
  • Rationale for electrical parameters

Scientific publication

  • Cephalalgia 2016
  • Internal Medicine Review 2017
  • Frontiers in Neurology​2017
  • Pain and Therapy journal 2015
  • Cephalalgia 2018
  • Cephalalgia 2018